A gazebo with columns, a large tree with hanging roots, and a building in the background.

Hotels in Santa Ana, Panama City

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (5,971 reviews)
"Beautiful hotel, breakfast was wonderful, location was very convenient."
United States
Sandrelly
The price is CA $193
CA $212 total
includes taxes & fees
Sep 28 - Sep 29
Hotel Riu Plaza Panama

2. Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive
4.0 star property
7.9 km from Santa Ana
7.8 out of 10, Good, (1,086 reviews)
"We had a wonderful stay at the resort, very relaxing and friendly atmosphere. Definitely recommending for family getaway."
United States
Joanna
The price is CA $389
CA $389 total
includes taxes & fees
Oct 1 - Oct 2
Dreams Playa Bonita Panama - All Inclusive

3. Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
Punta Paitilla, 3.5 km from Santa Ana
8.6 out of 10, Excellent, (1,742 reviews)
"It was a beautiful stay ..enjoyed every moment"
United States
Devika
The price is CA $194
CA $194 total
includes taxes & fees
Oct 1 - Oct 2
Megapolis Hotel Panamá

4. W Panama

W Panama
5.0 star property
Campo Alegre, 3.2 km from Santa Ana
9.0 out of 10, Wonderful, (1,002 reviews)
"Wonderful staff!"
United States
Nikkia
The price is CA $312
CA $343 total
includes taxes & fees
Oct 11 - Oct 12
W Panama

5. JW Marriott Panama

JW Marriott Panama
5.0 star property
Punta Pacifica, 4.3 km from Santa Ana
9.2 out of 10, Wonderful, (1,005 reviews)
"Great experience in great hotel You can’t be wrong if you book room with them, I will be back again for sure"
United States
Nemanja
The price is CA $368
CA $405 total
includes taxes & fees
Oct 4 - Oct 5
JW Marriott Panama

6. Marriott Panama Hotel

Marriott Panama Hotel
4.0 star property
2.1 km from Santa Ana
9.2 out of 10, Wonderful, (1,003 reviews)
"Great place to stay with the family."
United States
Richard
The price is CA $236
CA $260 total
includes taxes & fees
Oct 10 - Oct 11
Marriott Panama Hotel

7. Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
El Cangrejo, 3.9 km from Santa Ana
9.0 out of 10, Wonderful, (2,066 reviews)
"Good area around for short time visit"
United States
Eliel
The price is CA $83
CA $91 total
includes taxes & fees
Sep 22 - Sep 23
Principe Hotel and Suites

8. Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 0.9 km from Santa Ana
9.0 out of 10, Wonderful, (1,007 reviews)
"Great location and nice hotel."
United States
Olga
The price is CA $257
CA $282 total
includes taxes & fees
Oct 21 - Oct 22
Central Hotel Panama Casco Viejo

9. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 1.1 km from Santa Ana
9.8 out of 10, Exceptional, (750 reviews)
"Amazing service and beautiful hotel"
United States
Jose
The price is CA $497
CA $547 total
includes taxes & fees
Oct 6 - Oct 7
Sofitel Legend Casco Viejo, Panama City

10. Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador, 2.3 km from Santa Ana
8.6 out of 10, Excellent, (1,002 reviews)
"It was a nice getaway if you didn't want to be directly in the city"
United Kingdom
Samantha
The price is CA $132
CA $145 total
includes taxes & fees
Sep 22 - Sep 23
Radisson Hotel Panama Canal

11. The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,261 reviews)
"great location, great hotel"
United States
Sandra
The price is CA $124
CA $136 total
includes taxes & fees
Oct 7 - Oct 8
The Executive Hotel

12. Hyatt Regency Panama City

Hyatt Regency Panama City
5.0 star property
Campo Alegre, 3.4 km from Santa Ana
9.6 out of 10, Exceptional, (456 reviews)
"One of the best hotel in Panama🔥"
United States
Abraham
The price is CA $262
CA $288 total
includes taxes & fees
Sep 27 - Sep 28
Hyatt Regency Panama City

13. Riande Urban Hotel

Riande Urban Hotel
3.5 star property
El Cangrejo, 3.8 km from Santa Ana
8.8 out of 10, Excellent, (1,035 reviews)
"It was an amazing place and center located to all restaurants and night life"
United States
Abraham
The price is CA $113
CA $126 total
includes taxes & fees
Oct 21 - Oct 22
Riande Urban Hotel

14. Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
4.0 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,159 reviews)
"Great breakfast options, Clean rooms, helpful staff"
United States
Abeke
The price is CA $89
CA $176 total
includes taxes & fees
Sep 26 - Sep 27
Waymore Hotel Spa & Casino

15. Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2,229 reviews)
"Great hotel, great location"
Canada
Catherine
The price is CA $144
CA $159 total
includes taxes & fees
Oct 10 - Oct 11
Plaza Paitilla Inn Hotel

16. Aloft by Marriott Panama

Aloft by Marriott Panama
3.5 star property
San Francisco, 5.7 km from Santa Ana
8.8 out of 10, Excellent, (1,003 reviews)
"It was a great stay"
United States
Shaniyah
The price is CA $167
CA $183 total
includes taxes & fees
Sep 27 - Sep 28
Aloft by Marriott Panama

17. Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1,346 reviews)
"excellent breakfast great location"
United States
Maria
The price is CA $137
CA $151 total
includes taxes & fees
Oct 3 - Oct 4
Ramada Plaza by Wyndham Panama Punta Pacifica

18. Hilton Panama

Hilton Panama
5.0 star property
Bella Vista, 3 km from Santa Ana
9.0 out of 10, Wonderful, (1,004 reviews)
"Amazing stay"
United States
Kevin
The price is CA $343
CA $377 total
includes taxes & fees
Oct 9 - Oct 10
Hilton Panama

19. Marriott Executive Apartments Panama City, Finisterre

Marriott Executive Apartments Panama City, Finisterre
4.0 star property
Campo Alegre, 2.9 km from Santa Ana
8.8 out of 10, Excellent, (764 reviews)
"Great hotel, good breakfast friendly staff"
United States
Kitania
The price is CA $150
CA $165 total
includes taxes & fees
Sep 22 - Sep 23
Marriott Executive Apartments Panama City, Finisterre

20. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
7.5 km from Santa Ana
8.2 out of 10, Very good, (1,000 reviews)
"Great place, well maintained, greate restaurants, staff very respectful."
Canada
Flavio
The price is CA $288
CA $317 total
includes taxes & fees
Oct 2 - Oct 3
The Westin Playa Bonita Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Santa Ana

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers
Casco View Life Residences
4.0 star property
9.0
Wonderful
106 reviews
View
Interior
Hotel Caracas - Casco Viejo
3.0 star property
8.0
Very good
16 reviews
View
Bar (on property)
Hostal La Cigarra
2.0 star property
7.6
Good
73 reviews
View
Double Room | View from room
Hotel República
2.0 star property
6.8
197 reviews
View
Front of property
ART CASCO The Hotel
2.0 star property
6.0
13 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Top Santa Ana Hotel Reviews

Find out more about Santa Ana

Top reasons to visit Santa Ana

  • Historical Attractions: Visit significant sites like the Santa Ana Church and Iglesia Santa Ana to experience the rich cultural heritage of the area.
  • Charming Walking Tours: Enjoy guided walking tours led by locals, showcasing the unique charm and highlights of Santa Ana.
  • Relaxing Green Spaces: Spend time at Santa Ana Square, a perfect spot for relaxation and enjoying scenic views.
  • Diverse Accommodations: Choose from a wide range of lodging options, from budget to luxury, catering to all types of travelers.
  • Proximity to Attractions: Easily access nearby popular attractions like Casco Viejo and Parque Natural Metropolitano for day trips.

Find great hotels near Santa Ana

Santa Ana boasts a diverse selection of accommodations, catering to every traveler's needs, from budget-friendly lodgings to luxurious 5-star hotels. Whether you're seeking a charming lodge or a modern hotel, you'll find options that provide essential services for city exploration, business trips, or a pet-friendly getaway. Discover the best hotels in Santa Ana and enjoy a memorable stay in the heart of Panama City.

  • Central Hotel Panama Casco Viejo: Nestled in the vibrant Casco Viejo district, Central Hotel Panama offers a romantic and luxurious environment perfect for couples and business travellers alike. This 4-star gem is renowned for its exceptional spa services, featuring a full-service spa, steam room, and facial treatments to soothe your senses. With a strong focus on romance, guests can indulge in packages that include champagne service and 24-hour room service. For business needs, the hotel provides accessible meeting rooms and conference spaces, ensuring a seamless experience for professionals.
  • American Trade Hotel: Located in the heart of Panama City, the American Trade Hotel blends adventure, family-friendly amenities, and romantic touches into a unique lodging experience. This 4.5-star hotel boasts proximity to outdoor activities such as biking, hiking, and even Segway rentals, making it ideal for adventurous families. Guests can enjoy garden views from the restaurant while savouring limited-hour room service and champagne service. The outdoor pool area, complete with sun loungers and in-room massage options, provides a relaxing retreat for couples seeking a romantic getaway.
  • Sofitel Legend Casco Viejo, Panama City: This 5-star luxury hotel embodies elegance and sophistication in the historic Casco Viejo area. With a strong emphasis on business and leisure, it offers accessible business centres and comprehensive facilities for corporate travellers. Guests can unwind at the spa, which features treatment rooms and a swim-up bar, perfect for relaxation after a busy day. The hotel's exquisite design and top-notch services make it a premier choice for discerning travellers looking for an unforgettable experience in Panama City.

Where to stay near Santa Ana

Santa Ana, a vibrant neighbourhood in Panama City, offers a delightful mix of family-friendly activities and historical charm. Explore the bustling streets filled with friendly locals, and immerse yourself in the unique atmosphere of Panama's capital. Nearby, attractions like the historic Casco Viejo and the scenic Parque Natural Metropolitano provide perfect day trips. Whether you’re seeking a city-themed adventure or a relaxing family holiday, Santa Ana is an ideal base for discovering the rich culture of Panamá Province.

  • Panama City: As the vibrant capital of Panama, Panama City is a bustling metropolis rich in culture and history. Nestled in the heart of the country, it offers a diverse travel experience, appealing to families, business travellers, and city explorers alike. The city showcases a stunning mix of modern skyscrapers and colonial architecture. Visitors can enjoy shopping at prominent centres and malls, while the nearby beaches, parks, and lively streets invite exploration and relaxation. With visitor numbers peaking in January, July, and September, it's an ideal destination year-round.
  • Casco Viejo: Located a mere 644m from Santa Ana, Casco Viejo is a UNESCO World Heritage site known for its charming cobblestone streets and historic buildings. This neighbourhood is a hub of activity, making it perfect for families and city adventurers. With vibrant shopping centres, resorts, and delightful dining options, Casco Viejo is a picturesque setting for exploration. Enjoy the nearby beaches and parks, as well as the unique street life that adds to its cultural richness. Peak visitor months include January and March to April, offering a lively atmosphere.
  • San Felipe: Also situated 644m away from Santa Ana, San Felipe is a captivating neighbourhood known for its historic significance and charming streets. This area attracts families, business travellers, and city explorers, offering a mix of shopping malls and local boutiques. Visitors can explore the nearby beaches, historic places, and monuments that tell the story of Panama's past. With peak tourist arrivals from December to February, San Felipe provides a vibrant yet tranquil atmosphere for a memorable vacation.

Things to do near Santa Ana

Santa Ana, a vibrant neighbourhood in Panama City, is perfect for family and business vacations. Visitors can enjoy a variety of activities, including exploring shopping malls and unique shopping areas. Don't miss the chance to embark on a walking tour of Santa Ana, guided by knowledgeable locals, to discover touristy spots and enjoy pleasant strolls through this charming district.

Shopping

In Santa Ana, you can visit Avenida Central, located 483m away, offering a vibrant mix of family-friendly shops and entertainment. Albrook Shopping Mall, just 1.6km away, is perfect for family outings. If you're up for a drive, check out Uruguay Street, located 3.2km away, for more local shopping experiences.

Recreation

Experience the vibrant atmosphere at Maracana Stadium, located 1.3km from Santa Ana, perfect for sports enthusiasts. For an exhilarating outing, head to Estadio Nacional Rod Carew, 9.7km away, or Estadio Rommel Fernandez, 11.3km away, both offering thrilling sports events and energetic vibes.

Adventure

Embark on the Honeycreeper Ridge Trail, located 211.3km from Santa Ana, for a scenic hike surrounded by vibrant nature. For a thrilling experience, visit Gatun Eco Adventures, situated 48.3km away, where you can soar through the treetops on an exhilarating zipline ropes course.

Nightlife

Experience the vibrant nightlife in Santa Ana by visiting Crown Casino, just 3.2km away, for thrilling games and romance. For a cultural evening, enjoy a show at the National Theater (0.9.7km away) or Anita Villalaz Theater (1.3km away), both offering family-friendly entertainment and a romantic atmosphere.

Booking tips and Expedia advantages for Santa Ana

When visiting Santa Ana, Panama, consider exploring free attractions like Albrook Shopping Mall and Cinta Costera. To save on accommodation, travel during the off-peak months from September to November, when prices are lower compared to peak times like March and December to January. Tuesdays are typically the cheapest days to stay, while Saturdays are the most expensive. Use Expedia to compare prices and book packages that combine flights and hotels for added savings. Don't forget to filter for eco-certified hotels to find sustainable options that fit your budget.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santa Ana are September to November, where the prices are slightly lower. This is in comparison to March and December to January, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santa Ana is Tuesday. The most expensive day to stay around Santa Ana is Saturday.
  • Find cheap hotels on Expedia: Expedia’s search tool enables you to choose your budget, preferred location, and additional criteria. You can easily sort your results to display prices from lowest to highest, allowing you to find the most affordable hotels right away. Additionally, you can refine your choices by hotel type—select the "Eco-certified" filter to discover sustainable and environmentally-friendly accommodations available for booking.
  • Consider bundling your trip: You can save money by combining your Santa Ana hotel reservation with your flights and activities when you book an Expedia package.

Find the best attractions near Santa Ana

Santa Ana, located in Panama City, is perfect for family and business vacations, offering a rich cultural experience. Visitors can explore historical sites such as the Santa Ana Church and Iglesia Santa Ana, relax at Santa Ana Square, and enjoy scenic views near the canyon. The area's attractions cater to those seeking a blend of history and city life, making it an ideal destination for tourists looking to immerse themselves in local culture.

  • Metropolitan Cathedral of Panama: Located 805m from Santa Ana, this stunning cathedral showcases remarkable colonial architecture and intricate artwork. It serves as a cultural hub, offering a glimpse into Panama's rich history and religious heritage.
  • Ancon Hill: Just 966m from Santa Ana, Ancon Hill provides breathtaking panoramic views of Panama City and the Panama Canal. This outdoor oasis is perfect for hiking and enjoying nature while immersing yourself in the area's scenic beauty.
  • Interoceanic Canal Museum: Situated 805m away, this museum is dedicated to the history of the Panama Canal. It features fascinating exhibits that highlight the canal's significance, making it a must-visit for culture enthusiasts.

Best time to go to Santa Ana

Visitor numbers around Santa Ana is generally unchanged in popularity throughout the year. The best time to visit Santa Ana can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Santa Ana falls in April, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature around Santa Ana falls in November, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January78.8°F (26.0°C)No Rain (Dry)Mostly SunnySlightly HighSlightly High
February79.2°F (26.2°C)No Rain (Dry)Mostly SunnySlightly HighAverage
March79.7°F (26.5°C)No Rain (Dry)Mostly SunnyAverageSlightly High
April80.4°F (26.9°C)Light RainMostly SunnyAverageAverage
May80.2°F (26.8°C)Frequent RainMostly CloudySlightly LowAverage
June79.9°F (26.6°C)Frequent RainMostly CloudySlightly LowAverage
July79.3°F (26.3°C)Frequent RainMostly CloudyAverageAverage
August79.2°F (26.2°C)Frequent RainMostly CloudyAverageAverage
September79.3°F (26.3°C)Frequent RainMostly CloudySlightly LowSlightly Low
October78.6°F (25.9°C)Frequent RainMostly CloudyAverageSlightly Low
November78.3°F (25.7°C)Frequent RainMostly CloudyAverageSlightly Low
December78.6°F (25.9°C)Light RainMostly CloudySlightly HighSlightly High

The nearest major airports for your trip to Santa Ana

When visiting Santa Ana, you have convenient access to two major airports. Panama City (PTY-Tocumen Intl.) is located 20.9km away, with notable hotels like The Santa Maria, A Luxury Collection Hotel & Golf Resort, 8.0km from the airport, and JW Marriott Panama, 16.1km away. Alternatively, Panama City (PAC-Marcos A. Gelabert Intl.) is only 3.2km from Santa Ana, featuring excellent accommodations such as Waldorf Astoria Panama, just 3.2km away, and Hilton Panama, 4.8km away. Transportation services from these hotels to the airports typically include on-request shuttle services, offering ease and comfort for your travel needs.

Frequently asked questions

What are the best hotels in Santa Ana that travellers recommend?
For a popular hotel in Santa Ana, consider Hostal La Cigarra.

Hostal La Cigarra, with a rating of 7.6, is particularly noted by guests for its convenient location and comfortable rooms. This property features a traditional design and is situated within a historical district, close to a shopping district. It is also very convenient for visiting local attractions, being only 0.6 km from the Museum of History Panama and the Mola Museum. Other nearby points of interest include Cinta Costera, 1.6 km away, and Avenida Balboa, 3.6 km away.
What are the top pet-friendly hotels in Santa Ana?
For a top pet-friendly hotel in Santa Ana, you should consider Hostal La Cigarra.

Hostal La Cigarra, with a 7.6 rating, is a pet-friendly accommodation that permits pets and charges a cleaning amount for them. It is located in a historical district, making it convenient for exploring sites like the Museum of History Panama and the Mola Museum, both just 0.6 km away. Guests have frequently commented on its convenient location and comfortable rooms.
What are the best budget hotels in Santa Ana?
For budget-friendly accommodation in Santa Ana, you might consider Hostal La Cigarra, Hotel República, or ART CASCO The Hotel.

Hostal La Cigarra, with a rating of 7.6, provides free WiFi and is located in a historical district, close to the Amador Theater and the Museum of History Panama. Guests often comment on its convenient location and comfortable rooms.

Hotel República offers free WiFi and a lovely terrace, including a rooftop terrace, for guests to enjoy. It is also situated within a historical district.

ART CASCO The Hotelprovides free WiFi and is conveniently located near museums and a historical district. It also offers nearby offsite parking with a discount.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Santa Ana hotel for you.
How much is the nightly rate at a Santa Ana hotel?
Hotel prices in Santa Ana often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

Explore a world of travel with Expedia