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Our top choices for Santa Ana hotels

1. Hotel Riu Plaza Panama
Hotel Riu Plaza PanamaCampo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (6,180 reviews)
The price is CA $184
CA $203 total
includes taxes & fees
Dec 1 - Dec 2

2. Dreams Playa Bonita Panama - All Inclusive
Dreams Playa Bonita Panama - All Inclusive7.9 km from Santa Ana
7.8 out of 10, Good, (1,123 reviews)
The price is CA $367
CA $367 total
includes taxes & fees
Dec 1 - Dec 2

3. Megapolis Hotel Panamá
Megapolis Hotel PanamáPunta Paitilla, 3.5 km from Santa Ana
8.6 out of 10, Excellent, (1,841 reviews)
The price is CA $184
CA $203 total
includes taxes & fees
Nov 11 - Nov 12

4. The Westin Playa Bonita Panama
The Westin Playa Bonita Panama7.5 km from Santa Ana
8.2 out of 10, Very good, (1,000 reviews)
The price is CA $301
CA $331 total
includes taxes & fees
Nov 15 - Nov 16

5. Central Hotel Panama Casco Viejo
Central Hotel Panama Casco ViejoSan Felipe, 0.9 km from Santa Ana
9.2 out of 10, Wonderful, (1,003 reviews)
The price is CA $278
CA $306 total
includes taxes & fees
Dec 7 - Dec 8

6. Ramada Plaza by Wyndham Panama Punta Pacifica
Ramada Plaza by Wyndham Panama Punta PacificaSan Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1,419 reviews)
The price is CA $133
CA $147 total
includes taxes & fees
Nov 16 - Nov 17

7. Marriott Panama Hotel
Marriott Panama Hotel2.1 km from Santa Ana
9.2 out of 10, Wonderful, (1,003 reviews)
The price is CA $249
CA $274 total
includes taxes & fees
Dec 4 - Dec 5

8. Sofitel Legend Casco Viejo, Panama City
Sofitel Legend Casco Viejo, Panama CitySan Felipe, 1.1 km from Santa Ana
9.8 out of 10, Exceptional, (771 reviews)
The price is CA $656
CA $722 total
includes taxes & fees
Nov 29 - Nov 30

10. Waymore Hotel Spa & Casino
Waymore Hotel Spa & CasinoEl Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,224 reviews)
The price is CA $121
CA $212 total
includes taxes & fees
Nov 13 - Nov 14

11. Hilton Panama
Hilton PanamaBella Vista, 3 km from Santa Ana
9.0 out of 10, Wonderful, (1,004 reviews)
The price is CA $349
CA $384 total
includes taxes & fees
Dec 4 - Dec 5

12. The Executive Hotel
The Executive HotelCampo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,306 reviews)
The price is CA $112
CA $123 total
includes taxes & fees
Nov 23 - Nov 24

13. Principe Hotel and Suites
Principe Hotel and SuitesEl Cangrejo, 3.9 km from Santa Ana
9.0 out of 10, Wonderful, (2,134 reviews)
The price is CA $83
CA $91 total
includes taxes & fees
Nov 7 - Nov 8

14. Plaza Paitilla Inn Hotel
Plaza Paitilla Inn HotelPunta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2,240 reviews)
The price is CA $164
CA $181 total
includes taxes & fees
Nov 9 - Nov 10

15. Radisson Hotel Panama Canal
Radisson Hotel Panama CanalAmador, 2.3 km from Santa Ana
8.6 out of 10, Excellent, (1,007 reviews)
The price is CA $109
CA $120 total
includes taxes & fees
Nov 9 - Nov 10

16. Hyatt Regency Panama City
Hyatt Regency Panama CityCampo Alegre, 3.4 km from Santa Ana
9.6 out of 10, Exceptional, (499 reviews)
The price is CA $349
CA $384 total
includes taxes & fees
Dec 6 - Dec 7

17. JW Marriott Panama
JW Marriott PanamaPunta Pacifica, 4.3 km from Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
The price is CA $457
CA $503 total
includes taxes & fees
Nov 27 - Nov 28

18. Aloft by Marriott Panama
Aloft by Marriott PanamaSan Francisco, 5.7 km from Santa Ana
8.8 out of 10, Excellent, (1,010 reviews)
The price is CA $164
CA $181 total
includes taxes & fees
Nov 15 - Nov 16

19. Riande Urban Hotel
Riande Urban HotelEl Cangrejo, 3.8 km from Santa Ana
8.8 out of 10, Excellent, (1,041 reviews)
The price is CA $112
CA $123 total
includes taxes & fees
Nov 8 - Nov 9

20. Hotel La Compañía Casco Antiguo
Hotel La Compañía Casco AntiguoSan Felipe, 0.9 km from Santa Ana
9.8 out of 10, Exceptional, (373 reviews)
The price is CA $457
CA $503 total
includes taxes & fees
Dec 1 - Dec 2
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in Santa Ana
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Casco View Life Residences | 9.0 Wonderful 114 reviews | View | ||||||
![]() Hotel Caracas - Casco Viejo | 7.6 Good 31 reviews | View | ||||||
![]() La Manzana Barrio Vivo by Wynwood | 7.6 Good 21 reviews | View | ||||||
![]() Hostal La Cigarra | 7.6 Good 76 reviews | View | ||||||
![]() Hotel República | 6.8 197 reviews | View |
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Photo by Fabiola Tile
Open Photo by Fabiola Tile
Bella Vista
Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

El Cangrejo
The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

San Francisco
San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe
If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.


















































































































